Abstract
Serum deprivation response (SDPR) is a plasma membrane binding protein and a substrate of protein kinase C (PKC) phosphorylation, which recruits polymerase I and transcript release factor (PTRF) to caveolae to stabilize and define their morphology. But how they were transported to membrane remain unclear. In order to clarify the link of SDPR and cytoskeleton, we observed the localized relationship between SDPR and cytoskeleton proteins by Immunofluorescence. Here, we discovered that SDPR colocalizes with cortactin (CTTN) in A7r5. Interestingly, SDPR was found to be highly concentrated in podosomes and dorsal ruffles induced by Phorbol 12, 13-dibutyrate (PDBu), and platelet-derived growth factor (PDGF), respectively, which suggest a possible role of SDPR in cell motility and cell invasion.
Published Version
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