Abstract
Substance P (SP) caused a concentration-dependent increase in short-circuit current of rat isolated colonic mucosal preparations (ED50 10 nM). The SP antagonist [D-Arg1,D-Pro2,D-Trp7,9, Leu11]SP (50 microM) did not increase short-circuit current. Tetrodotoxin (3.1 microM) reduced the effect of a maximum concentration of SP (300 nM). This reduction was increased when tetrodotoxin was given with [D-Arg1,D-Pro2,D-Trp7,9,Leu11]SP. Increases in short-circuit current produced by electrical field stimulation were not reduced by [D-Arg1,D-Pro2,D-Trp7,9,Leu11]SP. It is concluded that SP is not a transmitter at the neuroepithelial junction in rat colonic mucosa.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
