Abstract
Objective:To evaluate the anti-ulcer activity of ethanol extract of leaves of Polyalthia longifolia (Sonn.) Thwaites.Materials and Methods:The ethanol extract of Polyalthia longifolia was investigated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats at 300 mg/kg body weight.p.o.Results:A significant (P < 0.01, P < 0.001) anti ulcer activity was observed in all the models. Pylorous ligation showed significant (P< 0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 89.71% ulcer inhibition in HCl- Ethanol induced ulcer and 95.3% ulcer protection index in stress induced ulcer.Conclusion:This present study indicates that P. longifolia leaves extract have potential anti ulcer activity in the three models tested.
Highlights
Materials and Methods: The ethanol extract of Polyalthia longifolia was investigated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats at
Pylorous ligation showed significant (P
In aspirin plus pylorus ligation induced gastric ulcer model the ethanol extracts of P. longifolia reduced the gastric volume, free acidity, total acidity and ulcer index showing the anti-secretory mechanism involved in the extracts for their anti-ulcerogenic activity
Summary
The ethanol extract of Polyalthia longifolia was investigated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats at300 mg/kg body weight.p.o. The ethanol extract of Polyalthia longifolia was investigated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats at. The leaves of Polyalthia longifolia was collected from. The specimen voucher was deposited in the Asthagiri Herbal Research. The leaves of P. longifolia were air-dried and powdered plant material was extracted by maceration with ethanol for. The extract was concentrated using rotary vacuum to get Indian J Pharmacol. | Jun 2008 | Vol 40 | Issue 3 | 126-128 the solid mass. The extract, ranitidine, sucralfate and omeprazole were suspended in 1%
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