ANTIULCER ACTIVITY OF METHANOLIC LEAVES EXTRACT OF NERIUM INDICUM MILL.

Govind Patel,Shobhit Shrivastava,Satish Nayak

doi:10.7439/ijbr.v1i2.59

Govind Patel, Shobhit Shrivastava + Show 1 more

Open Access

https://doi.org/10.7439/ijbr.v1i2.59

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Abstract

The objective of present study is to evaluate the anti ulcer activity of methanol extract of leaves of Nerium indicum. The methanol extract of N. indicum was investigated for its anti ulcer activity against plus pylorus ligation induced gastric ulcer and indomethacin induced ulcer in rats. The antiulcer activity was assessed by determining and comparing gastric volume, free acidity, total acidity, pH and ulcer inhibition in plus pylorus ligation induced gastric ulcer model and mean score value of ulcer inhibition in indomethacin induced ulcer model. A significant antiulcer activity was observed in all the models. Pylorus ligation model showed significant (P 0.001, P 0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. Also extract showed 69.63 % ulcer inhibition in indomethacin induced ulcer. This present study indicates that Nerium indicum leaves extract have potential anti ulcer activity in the two models tested.

Highlights

Nerium indicum Mill. (Family: Apocynaceae) it is an ever green plant with a long history of traditional medicinal uses in many countries in the world, especially tropical and subtropical countries [1]
The present study was undertaken to study the effect of methanolic leaves extract of Nerium indicum on pylorus ligation and indomethacin induced ulcer in rats
The fresh leaves of Nerium indicum Mill was collected from Sagar,Madhya Pradesh, India

Summary

Introduction

Nerium indicum Mill. (Family: Apocynaceae) it is an ever green plant with a long history of traditional medicinal uses in many countries in the world, especially tropical and subtropical countries [1]. The present study was undertaken to study the effect of methanolic leaves extract of Nerium indicum on pylorus ligation and indomethacin induced ulcer in rats. The fresh leaves of Nerium indicum Mill was collected from Sagar,Madhya Pradesh, India. The powdered plant material (100 g) was repeatedly extracted in a 500 mL round bottomed flask with 300 mL solvents of increasing polarity starting with petroleum ether and methanol. The acute toxicity for methanolic extracts of Nerium indicum was determined in albino mice, maintained under standard conditions.

Results

Conclusion