Abstract
IntroductionIn this study, patients before and after cardiac surgery with cardiopulmonary bypass (CPB) and control subjects were evaluated for erythrocyte glutathione peroxidase, catalase and superoxide dismutase enzyme activities, in addition to glutathione, malondialdehyde, serum total sialic acid, lipid-bound sialic acid, total antioxidant status, trace elements and mineral levels. The correlation of these variables with coronary artery disease (CAD) was also assessed.MethodsA total of 30 CAD patients and 30 control subjects were included in the study. CAD patients were divided into three groups: before surgery (BS), first day after surgery (1st day AS) and seventh day after surgery (7th day AS).ResultsMalondialdehyde (MDA) and total sialic acid (TSA) levels were significantly higher in CAD (BS) than in the control group (P<0.05, P<0.05). In addition, GSH and TAS levels were significantly lower in the 1st day AS group than in the control group (P<0.001, P<0.01). Moreover, Co, Cu, Mg, Se, V and Zn levels were significantly lower in CAD (BS) group than in the control group (P<0.01, P<0.01, P<0.01, P<0.01, P<0.05, P<0.001).ConclusionsIt was concluded that the levels of LDL-C, total cholesterol, triglycerides and CRP significantly associated with parameters, as well as Cu, Ca and SOD activity, should be measured together to monitor CAD. It is also considered that measuring TSA and MDA might be an appropriate choice for biomarkers of CAD.
Highlights
In this study, patients before and after cardiac surgery with cardiopulmonary bypass (CPB) and control subjects were evaluated for erythrocyte glutathione peroxidase, catalase and superoxide dismutase enzyme activities, in addition to glutathione, malondialdehyde, serum total sialic acid, lipidbound sialic acid, total antioxidant status, trace elements and mineral levels
According to the statistical analysis, comparison of coronary artery disease (CAD) patients and controls indicated a significant increase in blood urea nitrogen (BUN) (P
Inflammation and oxidative stress are associated with the pathogenesis of atherosclerosis and increase the risk of postoperative atrial fibrillation and graft failure[22] Trace elements are necessary for a wide range of primary cellular functions and are especially crucial for various enzymes involved in the generation and neutralization of Reactive oxygen species (ROS) that are normally produced by the cell[23]
Summary
Patients before and after cardiac surgery with cardiopulmonary bypass (CPB) and control subjects were evaluated for erythrocyte glutathione peroxidase, catalase and superoxide dismutase enzyme activities, in addition to glutathione, malondialdehyde, serum total sialic acid, lipidbound sialic acid, total antioxidant status, trace elements and mineral levels. The correlation of these variables with coronary artery disease (CAD) was assessed. Reactive oxygen species (ROS) upregulate atherosclerotic events such as cell infiltration, platelet activation, adhesion and migration These ROS oxidize cellular biomolecules, including lipids, nucleic acids and proteins, causing endothelial impairments[5]. Destruction of endothelium, disruption of the routine vasomotor system and increase in thrombosis thought to be caused by ROS are the mechanisms of atherogenesis[8]
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