Evaluation the serum matrix metalloproteinase-2 and B-type natriuretic peptide in heart failure patients

Abstract

Heart failure is a complicated medical syndrome in which dyspnea or stress discomfort due to impairment of blood ejection, ventricular filling, or a combination of both, occurs as it develops. Heart failure is the last stage of cardiovascular diseases. Heart failure is diagnosed by using various parameters such as physical examination to determine clinical signs and symptoms, echocardiography, which provides detailed information on heart function and structure, and specific laboratory tests such as natriuretic peptide brain (BNP) and terminal N-proBNP (NT-proBNP). This study aimed to estimate biomarkers (Matrix Metalloproteinase-2 and Brain Natriuretic Peptide) in patients with heart failure and their relation with body mass index and volume of ejection fraction. This study is case control study was performed on 90 individuals divided into two groups. Group 1 represented patient with heart failure and group 2 represented control. The study carried out in Tikrit City, Salahaddin Governorate, Salahaddin Hospital from November of 2020 to February 2021. blood sampling performed from the patients and control groups. Measurement of Matrix Metalloproteinase-2 and Brain Natriuretic Peptide as done by colorimetric technique. The study showed significant difference in serum BNP and MMP-2 (119.36±18.12 pg/ml) and (48.18±2.74 ng/ml) respectively compared with apparently healthy group.The Pearson correlation test showed negative correlation between BNPand MMP-2 with ejection fraction in patients group. Also, the correlation between BMI with BNP and MMP-2 was different, whereas negative with BNP and positive with MMP-2. As well as, the positive correlation was found between BNP and MMP-2 in patient group. In conclusion, the data of current study demonstrate correlations between BNP and MMP-2 with percentage of ejection fraction in patients with heart failure. Effect of the body mass index on BNP and MMP-2 decrease with heart failure. Further studies should be applied to confirm this data in a larger number of patients and to clarify the mechanism.