Evaluation the Sensitivity and Specificity of Fucose and Some Biochemical Parameters as an Indicator of Therapeutic Response to Metformin in Polycystic Ovary Syndrome

Abstract

The present study aimed to evaluate the sensitivity and specificity of fucose and some biochemical parameters, as an indicator of therapeutic response to Metformin in patients with recently diagnosed with Polycystic Ovary Syndrome-PCOS undergoing treatment. This study was conducted from 1/9/2022 to 1/11/2022. In 90 blood samples were collected from women aged between (35-18) years old. Of these, 30 samples were taken from women who had recently been diagnosed with polycystic ovary syndrome as a first group-G1, and another 30 samples were taken from the same group of women after taking metformin medication as second group-G2, compared to 30 samples taken from healthy women with no history of the disease (as a control group-C). Samples were collected from women's clinics and external laboratories (after diagnosis from the doctor) in Samarra city/ Salah Ul-Din. The study includes determination of the concentration of sex hormones(Follicle stimulating hormone-FSH, luteinizing hormone-LH, and testosterone) and some biochemical parameters(Galactose, blood glucose, total fucose-TF, and fucose binding protein-FBP) in sera of samples under investigation. There was a significant increase in the levels of FSH and Glucose in a G1 at a probability level (P≤0.05). However, there was a significant decrease in total fucose and FBP, with no-significant difference in the levels of LH, testosterone, Galactose as compared with the control group. There was a significant increase in G2 at a probability level (P≤0.05) in the levels of Testosterone, Galactose, glucose with a significant decrease in the levels of TF and FBP, with no-significant difference in the level of LH, FSH and transaminases enzymes as compared with the control group. The study also include study the Receiver operating characteristic-ROC , In G1 as compared with C showed that the Sensitivity was also recorded as highest for galactose , In G2 as compared with C showed that the area under curve was outstanding for galactose, Sensitivity was also recorded as highest for galactose , In G1 as compared with G2 showed that the area under curve was outstanding for galactose. Sensitivity was also recorded as highest for galactose, then for Testosterone and total fucose. From the above results we can conclude that the level of fucose may be used as a diagnostic biomarker for polycystic ovary syndrome and also for treatment response with metformin. We conclude from the current study that the level of fucose may be considered a diagnostic indicator for polycystic ovarian cysts, as well as an indicator of the therapeutic response to uremia in patients.