Evaluation the Role of Preptin Hormone and some Biochemical Parameters in Type2 Diabetic Patients with Cardiovascular disease

Abstract

T2DM and coronary artery disease (CAD) pose significant threats worldwide, contributing to excessive morbidity and death; these co-morbidities interact synergistically with inflammatory processes. The study's goal was to look at Preptin, Lactate dehydrogenase (LDH), and Fasting Blood Glucose (FBG) levels. Serum Preptin, LDH and FBG levels were determined in 50 patients with acute myocardial infarction, 50 patients with (type 2 diabetes with myocardial infarction) and 50 healthy subjects. The results demonstrate a substantial rise in serum concentrations of (Preptin, LDH, and FBG) in the (T2DM with AMI) group as compared to the (AMI and controls) groups (p0.05). However, there was no significant difference in serum Preptin and FBG concentrations between the (AMI and controls) groups (p≤0.05). There was also no significant difference in serum LDH concentrations between the (AMI with T2DM and AMI) groups (p≤0.05). Assessment of Preptin with lactate dehydrogenase and fasting glucose may Predict pancreatic as well as cardiac dysfunction and its helpful in stratification of severity risk.