Abstract
IntroductionThere seems to be increasing evidence that inflammation leads to cancer. For several cancers, an association with white blood cell (WBC) count has been reported. So far, no studies have been performed for cancer of the oral cavity and WBC. Therefore, the aim of the present study was to look at whether WBC count can be used as a prognostic marker for recurrence or metastases for oral cancer.Material and methodsFor 278 patients with oral cancer, the preoperative WBC count was compared with the clinicopathological information: age, gender, T-status, N-status, recurrence, metastases, follow-up time, and time till recurrence or metastases appeared.ResultsOut of 278 patients, 48 developed recurrence, 24 second tumors, 46 cervical metastases, and 14 distant metastases. The mean follow-up time was 35.97 months (range: 12-107 months). Significant Pearson correlation at the 0.05 level could be found for the T-status (0.046), but not for the N status (0.121). No significant correlation could be found between WBC count and the development of recurrence or metastases.ConclusionIn conclusion, our findings demonstrate that elevated WBC count does not seem to be a predictor for recurrence or for further metastases. Further research is recommended to investigate the WBC count in precancerous lesions and in HPV positive patients with oral SCC.
Highlights
There seems to be increasing evidence that inflammation leads to cancer
No significant correlation could be found between white blood cell (WBC) count and the development of recurrence or metastases
In conclusion, our findings demonstrate that elevated WBC count does not seem to be a predictor for recurrence or for further metastases
Summary
There seems to be increasing evidence that inflammation leads to cancer. An association with white blood cell (WBC) count has been reported. No studies have been performed for cancer of the oral cavity and WBC. Associations between cancer and infections have been reported for several viruses, like human papilloma virus (HPV), human immunodeficiency virus (HIV), and chronic hepatitis B. Increasing evidence suggests that inflammation may be linked to the pathogenesis of cancer like M. Some authors have observed an association between elevated serum C-reactive protein (CRP) levels and some cancers, like colorectal [2,3], lung [4] and head and neck [5,6]. Concerning WBC count as a predictor for cancer, several studies have been performed [7,8,9]. The stromal tissues of tumors have a high WBC count, and the inflammatory cell number and their cytokines
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
