Evaluation of urine N-acetyl-β-D-glucosaminidase in renal tubular interstitial lesions of IgA nephropathy

Abstract

Objective To explore the clinical significance of urine NAG in judging the condition of renal tubular interstitial lesions in patients with IgA nephropathy (IgAN). Methods The data of 82 IgAN patients who had been clinical and pathological diagnosed in our hospital from February 2014 to June 2018 were collected. According to NAG normal level, all patients were divided into NAG normal group and high NAG group. The difference of clinic index and pathological scores between two groups were compared, and the clinical and pathological risk factor which have correlation with urine NAG were assessed. Results There had significant differences in Cr, micro-albumin(mALB), Cys-C, and NAG between two groups(P<0.05). The pathological lesion scores of mesangial cell proliferation, interstitial inflammatory cell infiltration, renal interstitial fibrosis, and tubular atrophy comparison between groups were compared. There were statistically significant differences(P<0.05). The correlation analysis showed that there were positive correlations of NAG with mALB, eGFR , renal interstitial inflammatory cell infiltration, renal tubular atrophy, renal fibrosis and the mesangial cell proliferation. Conclusions Urinary NAG levels are closely related to renal function, proteinuria and tubule-interstitial lesions, which can be used as clinical indicators to evaluate and monitor the degree of tubule-interstitial lesions in IgAN. Key words: Glomerulonephritis, IGA; Uridine Diphosphate N-Acetylglucosamine; Nephritis, Interstitial