Abstract
Recently, magnetic nanoparticles (MNPs), which can be manipulated in the magnetic field, have received much attention in tumor therapy. Extremely low frequency magnetic field (ELMF) system can initiate MNPs vibrating and the movement of MNPs inside of cells can be controlled by adjusting the frequency and intensity of ELMF towards irreversible cell damages. In this study, we investigated the detrimental effects on tumor cells with MNPs under various ELMF exposure conditions. An in-house built ELMF system was developed and utilized for evaluating the treatment efficiency of MNPs on tumor cells with specific intensities (2–20 Hz) and frequencies (0.1–20 mT). Significant morphological changes were found in tumor cells treated with MNPs in combing with ELMF, which were consistent with noticeable decrease in cell viability. With the increase of the intensity and frequency of the magnetic field, the structural integrity of tumor tissue can be further destroyed. Destructive effects of MNPs and ELMF on tumor tissues were further determined by the pathophysiological changes observed in vivo in animal study. Taken together, the combination of MNPs and ELMF had a great potential as an innovative treatment approach for tumor intervention.
Highlights
With the assistance magnetic nanoparticles (MNPs) inside of tumor cells, it is assumed that the loss of membrane integrity and morphological changes could be achieved under ELMF exposure, which could result in tumor cell damage
An innovative technique has been developed by using MNP-Fe3O4 under ELMF exposure to generated localized physical cell damage and eventually kills tumor cells
Comprehensive studies have reported the biological effects of external static or alterable magnetic field in the last decades[31,32,33,34,35,36,37,38,39]
Summary
We developed a novel ELMF system and evaluated the treatment efficiency on tumor cells with MNPs in ELMF with specific intensities and frequencies. Both in vitro and in vivo experiments were performed to determine the cell morphological changes and cell destruction following the exposure of ELMF with the presence of MNPs. To the best of our knowledge, no research has been explored in investigating the damage effects of MNPs and ELMF on tumor cells, which demonstrate promising potentials for tumor treatment
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