Abstract
Purpose: To evaluate the capabilities of ultrasound elastography in assessing the effectiveness of treatment of patients with special lesions of peripheral lymph nodes in lymphoproliferative lesions.Material and methods: To evaluate the capabilities of ultrasound elastography in assessing the effectiveness of treatment, an ultrasound study was carried out for 93 patients with lesions of peripheral lymph nodes with lymphoma in dynamics before treatment and after 2/3 courses of chemotherapy using Acoustic Force Radiation Impulse (ARFI — shear wave elastography) and eSie Touch (compression elastography).Results: Assessment of the dynamics of the average, minimum and maximum values of the shear wave velocity showed statistically significant differences. The most reliable changes were recorded when assessing the average and maximum indicators of the shear wave velocity (p = 0.0000001). Also, after two / three cycles of chemotherapy, the indicator X, XX m/s (p = 0.00001) was significantly less frequent, which was previously detected in the LN with the most rigid structure. Compression ultrasound elastography revealed softening of the LN structure in the form of an increase in the frequency of occurrence of I and II elastotypes.Conclusions: Our study confirms that ultrasound elastography allows, in a short time and without negative ionizing effects on the patient, to assess the effectiveness of the selected chemotherapy routes.
Highlights
Distribution of patients with lymphoma depending on the frequency of occurrence of gray-scale elastotypes Virtual TouchTM Tissue Imaging (VTI), according to the classification of Zhang F. et al [9], before treatment and during chemotherapy
Material and methods: To evaluate the capabilities of ultrasound elastography in assessing the effectiveness of treatment, an ultrasound study was carried out for 93 patients with lesions of peripheral lymph nodes with lymphoma in dynamics before treatment and after 2/3 courses of chemotherapy using Acoustic Force Radiation Impulse (ARFI — shear wave elastography) and eSie Touch
After two / three cycles of chemotherapy, the indicator X, XX m/s (p = 0.00001) was significantly less frequent, which was previously detected in the LN with the most rigid structure
Summary
Цель: Оценить возможности ультразвуковой эластографии в оценке эффективности лечения больных со специфическим поражением периферических лимфатических узлов при лимфопролиферативном поражении. Материал и методы: Для оценки возможностей ультразвуковой эластографии в оценке эффективности лечения проведено ультразвуковое исследование 93 больным лимфомой с поражением периферических лимфатических узлов в динамике до лечения и после 2/3 курсов химиотерапии с использованием технологий Acoustic Force Radiation Impulse (ARFI — эластография сдвиговой волной) и eSie Touch (компрессионная эластография). Для цитирования: Ковалева Е.В., Гудилина Е.А., Данзанова Т.Ю., Синюкова Г.Т., Лепэдату П.И. Оценка эффективности лечения лимфомы с поражением периферических лимфатических узлов методом ультразвуковой эластографии. На данный момент существуют лишь единичные работы, посвященные изучению возможностей мультипараметрического ультразвукового исследования в оценке эффективности лечения больных лимфомой с поражением периферических ЛУ. Squillaci E. et al произведена оценка возможности применения компрессионной эластографии в оценке эффективности лечения больных рефрактерной лимфомы Ходжкина (ЛХ) таргетным препаратом (брентуксимаб ветодин) [7]. Что необходимы дальнейшие исследования возможностей ультразвуковой эластографии в мониторинге ответа на лечение больных ЛХ [7]
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