Abstract
Aim: To evaluate the relationship between dynamic thiol-disulfide homeostasis which is a novel oxidative stress marker and levels of HBV DNA, and the oxidant-antioxidant balance. Material and Method: In the controlled study which included chronic hepatitis B (CHB) patients and healthy volunteers, dynamic Thiol-disulphide homeostasis (TDH) was measured using a novel automated method developed by Erel. Disulfide / total thiol (%), disulfide / native thiol (%), and native thiol / total thiol (%) rates were calculated using the previously determined concentrations of disulfides, native thiols, and total thiols. Results: Of thiol / disulfide homeostasis parameters, native thiol, total thiol, and disulfide levels were statistically lower in the CHB patient group (p <0.05). As a result of the correlation analyses, a significant negative correlation was determined between HBV DNA levels and disulfide / native thiol, disulfide / total thiol, and native thiol / total thiol parameters (p <0.05). Conclusions: Our results suggest that oxidative stress increases with the rise in HBV-DNA levels and that the antioxidant defense may have weakened.
Highlights
It is known that approximately two billion people in the world have encountered hepatitis B virus (HBV), and approximately 400 million people have chronic hepatitis B (CHB)
ALT levels were statistically higher in the patient group compared to the control group (p
Of thiol / disulfide homeostasis parameters, native thiol, total thiol, disulfide levels were statistically lower in the CHB patient group (p
Summary
It is known that approximately two billion people in the world have encountered hepatitis B virus (HBV), and approximately 400 million people have chronic hepatitis B (CHB). Every year approximately 600,000 people are estimated to have lost their lives due to HBV infection and/or associated complications [1, 2]. The natural course of the HBV infection is quite variable and is clinically well defined, the mechanisms underlying the pathogenesis of the disease have not been fully understood. The development of the body’s immune system, strength of the immune response, and properties of the virus are the most important factors determining the natural course [3]. A diagnosis of CHB is dependent on positive HBsAg findings for longer than a period of 6 months. HBeAg and HBV DNA levels are monitored in order to evaluate HBV replication [4]
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