Abstract
Objective: The present study was conducted to verify the effect of Caesalpinia bonducella and Cyclea peltata extracts on experimentally induced excision wounds in diabetic rats.Methods: Methanolic and ethyl acetate extract of test sample in PEG base was applied and observed for wound healing effect for a period of 15 d.Results: The data demonstrated statistically significant wound contraction up to 98% in the treated sample as compared to 90% in diabetic control group. The results correlated (r ³ 0.95) with fasting blood glucose level, indicating the deleterious effect of hyperglycemia in wound healing. Histopathological studies indicated moderate granulation with marked epithelial enclose and moderate hyperplasia in groups treated with high dose (100 mg/kg BW) of methanolic extract of aerial part of Cyclea peltata and root of Caesalpinia bonducella. Conclusion: From the study, it can be hypothesized that tested plant extracts favours wound healing in diabetic animals and paves the way for the more detailed study of the phytochemical constituent for therapeutic applications. The present investigation adds to the existing knowledge in the field of therapeutic medicine and may even become the base for the development of herbal based gel formulations or ointments for treating wounds in diabetic patients and thereby continuous usage of synthetic drugs, its associated side effects could be avoided.
Highlights
Wounds are unavoidable events of life, which arise due to physical, chemical injury or microbial infections
The summary of fasting blood glucose values of animals are presented in table 1
Streptozotocin induces diabetes through the destruction of beta cells of the pancreas which is evident in the present study by the rise in blood glucose level
Summary
Wounds are unavoidable events of life, which arise due to physical, chemical injury or microbial infections. The wound may be defined as a loss or breaking of cellular and anatomic or functional continuity of living tissues [1]. The wound healing process is a complex series of events that begins at the moment of injury and can continue for months to years. The basic principle of optimal wound healing is to minimize tissue damage and provide adequate tissue perfusion and oxygenation, proper nutrition and moist wound healing environment to restore the anatomical continuity and function of the affected part [2]. Healing of wounds requires the collaborative efforts of many different tissues and cell lineages [3]. The process involves different phases such as coagulation, epithelization, granulation, collagenation and tissue remodelling
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