Abstract
The role of Notch pathway in hepatocarcinogenesis is unclear with conflicting results reported from different researchers. This study aimed to investigate the exact role of Notch1 in hepatocarcinogenesis and its influence on survival and to determine the possibility of it being a target therapy. Differential immunohistochemical expression of Notch1 in 100 cases of hepatocellular carcinoma (HCC) and adjacent non-neoplastic liver tissue was performed. The results showed that expression of Notch1 was significantly higher in the non-neoplastic hepatic tissues than in HCC tissues (p<0.001), but there was no significant difference in Notch1 expression between cirrhotic and non-cirrhotic liver tissue (p=0.197). Notch1 expression was higher in low grade than in high grade HCC (p=0.036). Notch1 expression showed reverse correlation with mitotic count (p=0.008), and necrosis (p=0.005). The disease free survival was shorter in patients displaying low levels of Notch1 expression (p=0.045). The overall survival showed no significant difference between high and low levels of Notch1 expression; however, it was somewhat longer in patients with high Notch1 expression (p=0.220). In conclusion, the tumour suppressor role of Notch1 was supported and the use of Notch1 agonists may have a role in improving the prognosis of HCC.
Published Version
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