Abstract
Imprint cytology (IC) is an easy, quick and inexpensive diagnostic method. IC is an accurate and simple intra operative method for diagnosing breast lesions and also used for various lesions in the body. The present study aims at comparing the touch IC with histological diagnosis, evaluating the accuracy of IC in diagnosis of benign and malignant lesions of breast and to compare the validity of touch IC with Fine needle aspiration cytology (FNAC). This was a descriptive study done in collaboration with Department of General Surgery at Kamineni Institute of Medical Sciences (KIMS) hospital, Narketpally. Fifty cases of breast lesions were evaluated, comprising of benign & malignant lesions. Relevant clinical data were recorded in a proforma. Touch imprints were prepared from all the lesions and stained with rapid Haematoxylin & Eosin (H&E) and routine H&E stains. The imprints were subsequently compared with cytology and histopathology examinations. We observed better accuracy in IC (96%) than FNAC (89%) in correlation with histopathology, better sensitivity in IC (97.3%) than FNAC (93.3%) in correlated well with histopathology, better specificity in IC (92.3%) than FNAC (50%) in correlation with histopathology, Predictive value-97.29%, Negative predictive value-92.3%. All the imprints were well corroborated with FNAC & histopathological diagnosis. Thus, IC provides initial diagnosis to surgeons for immediate clinical and surgical intervention.
Highlights
Breast lesions which are more common in the females have gained increasing importance and attained global attention because of increasing mortality and morbidity caused by breast cancer
Imprint cytology is a rapid and inexpensive diagnostic procedure which is being used for the diagnosis of lesions at various sites in the body[8,9,10,14]
This descriptive study on 50 breast neoplastic lesions was conducted at Kamineni Institute of Medical Sciences (KIMS) hospital in collaboration with surgical department to assess the accuracy of Imprint cytology (IC) in breast lesions done in two years
Summary
Breast lesions which are more common in the females have gained increasing importance and attained global attention because of increasing mortality and morbidity caused by breast cancer. The patients present with a palpable mass, abnormalities in mammography and sometimes with sign of inflammation, nipple discharge[1,2]. Most of the breast lesions including carcinoma are potentially curable, if diagnosed early. IC, FNAC and mammography are being used regularly. Some of the diagnostic procedures are preoperative done like mammography, ultrasound, FNA, core needle biopsy. Some diagnostic modalities are used intra operatively like frozen section technique and IC. The most important role of diagnostic cytology in the assessment of breast lesions is to make a decision between benign and malignant categories. Procedures like FNA, core needle biopsy and imprints are useful in sampling of lesions whereas, the use of imaging modalities increases the visualization of lesions[12]
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