Evaluation of the relationship between preeclampsia and positive rectovaginal culture of group B Streptococcus and Helicobacter pylori positive serology

Samaneh Saghafian Larijani,Hosna Mirfakhraee,Maryam Niksolat,Maryam Biglari Abhari,Danesh Aminpanah

doi:10.34172/ipp.2022.21

Samaneh Saghafian Larijani, Hosna Mirfakhraee + Show 3 more

Open Access

https://doi.org/10.34172/ipp.2022.21

Copy DOI

Abstract

Introduction: Identifying the incidence of pathogen colonizations in pregnant women with preeclampsia can be effective in providing proper treatment and reducing complications. Objectives: We evaluated the frequency and association between positive rectovaginal culture of group B Streptococcus (GBS) and positive Helicobacter pylori serology with preeclampsia in two groups of pregnant women (with and without preeclampsia). Patients and Methods: The present case-control study included pregnant women with preeclampsia and healthy pregnant controls during 2019-2020. Blood and rectovaginal samples were obtained and the data were statistically analyzed using SPSS software. Results: Fifty-four people were included in the study. The mean gestational age was 36 ± 3.4 months in the preeclampsia group and 37 ± 2.9 months in the control group. There was no significant relationship between preeclampsia and H. pylori-positive serology (P=0.84). Additionally, the association between positive H. pylori serology and the severity of preeclampsia was not significant (P=0.15). However, there was a significant relationship between positive H. pylori tests with early- and late-onset preeclampsia (P=0.04). However, there was no statistically significant relationship between the positive rectovaginal culture of GBS and preeclampsia, the severity of preeclampsia, the onset time, or the weight of newborns. Conclusion: There was a significant relationship between H. pylori infection and late-onset preeclampsia in preeclamptic mothers. H. pylori screening and eradication therapy before pregnancy can prevent preeclampsia and its serious consequences in both the mother and the fetus.

Highlights

Behcet’s disease (BD) is a chronic, variable, multi-systemic vasculitis characterized by recurrent episodes of oral, genital, cutaneous and gastrointestinal ulcers and neurological, cardiovascular, ocular and articular manifestations [1]
This review aims to consider the role of auto-inflammatory and autoimmune processes and related factors which give rise to the different manifestations of the disease in each involved organ
BD is a multi-systemic disease whose etiology and pathogenesis remain poorly understood. It is characterized by a combination of autoimmune and autoinflammatory processes which appears to be related to genetic background and environmental factors

Summary

Introduction

Behcet’s disease (BD) is a chronic, variable, multi-systemic vasculitis characterized by recurrent episodes of oral, genital, cutaneous and gastrointestinal ulcers and neurological, cardiovascular, ocular and articular manifestations [1]. Involvement of the ocular, vascular and central nervous systems is considered an important cause of death [2]. Greco et al described otological impairments in patients with BD, including hearing loss and problems with balance [1]. The variable duration of successive attacks and episodes affecting different organs is the characteristic that distinguishes BD from other types of vasculitis [3]. The onset of severe inflammatory episodes of BD occurs mostly in the fourth decade of life, since the disease is not common in children and adults older than 50 years. Men are more susceptible than women [1,2]

Objectives

Findings

Conclusion