Abstract
The aim of the study was to evaluate the effect of Pterocarpus marsupium (PM) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. The rats were divided into five groups, each having six rats. PM extract 100mg and 200mg/kg was given orally to groups four and five, respectively, and standard drug sulfasalazine (100mg/kg, p.o) to group three. Group two served as UC control animals, and group one control animals received vehicle for 7days. UC was induced by administering AA (3% v/v of 2ml) to all the animals except group one. After 72h, the animals were killed and the colon was dissected out for microscopic, clinical evaluation, histopathological study and biochemical estimation. PM (100 and 200mg/kg)-treated group had significantly reduced colon inflammation and mucosal damage. The treatment also normalized the altered antioxidant enzyme levels (LPO, SOD and GSH). Histopathological studies support the effect. The protective effect of PM may be due to antiinflammatory and antioxidant properties.
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