Abstract
Aluminium is a hepatotoxic element that is extensively used in the production of household cookware, storage utensils, water purification and in the preparation of some drugs. Conversely, the leaf extract of Moringa oleifera is hepatoprotective amongst other medicinal and nutritional benefits.The present study evaluated the protective effect of ethanol leaf extract of Moringa oleifera on Aluminium induced hepatotoxicity in male albino wistar rats. Eighteen (18) male albino wistar rats weighing between140 and 180 g were divided into 3 groups of 6 animals per group. Group 1 served as control and was given normal rat chow and distilled water; Group 2 was administered 100 mg of Aluminium chloride per kg body weight whereas animals in Group 3 received 300 mg/kg body weight of ethanol leaf extract of Moringa oleifera and 100 mg per kg body weight of Aluminium chloride by oral gavage. The rats were sacrificed after 28 days of treatment. Blood and liver samples were obtained and used for the analyses of some marker enzymes (ALP, AST, ALT); haematological indices; lipid profile and histopathological assessment using standard techniques. The results show that Aluminium chloride increased the activities of ALP, ALT and AST significantly (P<0.05). TC, TG and LDL also increased significantly whereas HDL showed a significant decrease (P<0.05). The RBC count, Hb, PCV, lymphocytes and platelets decreased while WBC count and neutrophils increased significantly (P<0.05). Aluminium chloride caused alterations in the normal histology of the hepatocytes consistent with observed changes in enzyme activities. Administration of ethanol leaf extract of Moringa oleifera moderated the deleterious effects of Aluminium chloride.
Highlights
Introduction Moringa oleifera belongs to theMoringaceae family of perennial angiosperm plants
3.0 RESULTS Table 1 shows the effect of ethanol leaf extract of Moringa oleifera on Aluminium chloride induced increase in the activities of AST, ALT and ALP in male rats. This table indicates that treatment with Aluminium chloride (Group 2) precipitated a significant increase (p
Administration of aluminium chloride with ethanol leaf extract of Moringa oleifera ameliorated the dyslipidemia caused by Aluminium chloride (Group 3)
Summary
Introduction Moringa oleifera belongs to theMoringaceae family of perennial angiosperm plants. In Nigeria, Moringa oleifera is planted in all parts of the country and is identified by a variety of local names incuding, ‘Zogale’ (Hausa); ‘ewe igbale’ (Yoruba) and ‘ikwa oyibo’ (Ibo) (Thilza et al, 2010).The leaves, fruit, flowers and immature pods of Moringa oleifera are highly nutritious and have been utilized in ethnomedicine for the treatment of various human ailments (Anwar et al, 2007; Kumar et al, 2010). A variety of pharmacological activities have been attributed to the leaf extract of Moringa including anticancer, antiinflamatory, bactericidal, hypocholesterolemic, antiatherosclerotic, antioxidant, neuro and hepatoprotective (Buraimoh, 2011; Peixoto et al, 2011; Saalu et al, 2012; El-bakry et al 2016; Ekong et al, 2017)
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