Evaluation of the potential economic effects in the increased vaccination against meningococcal infection based on real epidemiological data

Abstract

Meningococcal infection (MI) is one of the heaviest illnesses with specific clinical picture and outcomes. MI prophylaxis is also actual from a social-economic viewpoint. Analysis based on RWD is important and should include epidemiological, medical, regional economic parameters as well as demographic data.Aim: economic evaluation of the potential outcomes of vaccination against MI in Far East Federal District of Russia (FER) in frames of vaccination growth in children.Materials and methods: Modelling of epidemiological and economic outcomes of MI vaccination with MenACWY-D vaccine in 95% of 3-year-old children in FER. Economic model usage cost vaccination, its efficacy, morbidity after vaccine usage, and mortality with such kind of parameters comparison w/o vaccination. The economic gain of vaccination is calculated in terms of the prevented loss of life years and the monetary equivalent of the per capita domestic regional product.Results: Vaccination against MI in 100 thousand children aged 3 years will decrease morbidity by 64,5% and mortality by 75% during 8 years after vaccination. Social gain is 5,8 mln RUR due to morbidity decrease and 1,3 bln RUR due to saving lives.Conclusion: Vaccination has an economic advantage — benefit after 100 thousand children vaccination up to 4,3 times higher than cost of vaccination in FER.