Evaluation of the periodontal status in acromegalic patients: a comparative study.

Ali N Harb,Matthias Nauck,Nele Friedrich,Thomas Kocher,Birte Holtfreter,Henri Wallaschofski

doi:10.5402/2012/950486

Abstract

Aim. The aim was to compare the periodontal status of the acromegalic patients with healthy subjects from a large population-based cohort (Study of Health in Pomerania, SHIP). Materials and Methods. We studied 32 acromegalic patients (16 females) and 128 randomly selected SHIP subjects (controls) using a 1 : 4 matching. Serum IGF-I and IGFBP-3 levels were measured using the Immulite 2500 system. Periodontitis was assessed by clinical attachment loss (CAL), probing depth (PD), and number of missing teeth. Linear and logistic regression models were used to assess differences in periodontal variables between acromegalic patients and controls. Results. IGF-I levels were comparable in acromegalic patients and controls, whereas IGFBP-3 levels were significantly higher in acromegalic patients (P = 0.004). In multivariate modelling, both groups did not differ significantly with respect to mean CAL (P = 0.12) and high tooth loss (P = 0.36). Mean PD was higher in acromegalic patients by trend (B = 0.28 (−0.00; 0.56)). Conclusion. In acromegalic patients, periodontal disease severity did not differ from their healthy SHIP controls.

Highlights

Periodontitis is considered the most common chronic infection in adults
In more than 95% of the cases, acromegaly is caused by a benign pituitary adenoma which develops from the somatotropic cells, leading to hypersecretion of growth hormone (GH) and subsequently to elevated serum levels of insulin-like growth factor hormone-I (IGF-I) [4, 5]
Serum IGF-I levels were comparable in both groups, whereas serum IGF binding protein-3 (IGFBP-3) levels were significantly higher in acromegalic patients compared with controls (P = 0.004)

Summary

Introduction

Periodontitis is considered the most common chronic infection in adults. It is an inflammatory disease, which results in alveolar bone loss and degeneration of periodontal tissues [1]. IGF-I is a polypeptide hormone, which is mainly secreted by the liver as a result of stimulation by growth hormones (GH) and mediates most of the endocrine actions of GH [6]. It plays an important anabolic rule in the periodontal ligament and contributes to the regeneration of lost periodontal tissue [7, 8]. Free serum IGF-I is considered the biologically active form of IGF-I [11]

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Conclusion