Abstract

BACKGROUND: Involutional skin changes in middle-aged and elderly women significantly reduce their quality of life, and comorbidities such as metabolic syndrome accelerate skin aging because these conditions are characterized by a common pathogenetic response with the impaired function of the microcirculation-tissue system. Preformed physical factors can improve microhemodynamics and reduce insulin resistance events. AIM: The aim of the study is to evaluate the effectiveness of the combined use of transcranial magnetic field therapy and hyperbaric oxygen therapy for treatment of involutional skin processes in middle-aged and elderly patients with metabolic syndrome. MATERIALS AND METHODS: The study included patients (n=90) with involutional skin changes. Patients with metabolic syndrome (60/90) were divided into a control group (hyaluronic acid injections) and an experimental group (addition of transcranial magnetic field therapy and hyperbaric oxygen therapy). The results were evaluated based on changes in parameters of the microcirculation-tissue system, carbohydrate and lipid metabolism disorders, and the quality of life of patients. RESULTS: The metabolic syndrome due to impaired function of the microcirculation-tissue system is shown to accelerate progression of involutional skin changes. Combined physical therapy significantly improves function of the microcirculation-tissue system of the skin, restores tissue perfusion, nutritive blood flow, oxygen metabolism, and oxidative phosphorylation activity. The changes observed, together with the reduced insulin resistance and the optimized metabolic responses, suggest an improvement in skin trophism due to adaptive microhemodynamic responses. CONCLUSION: Taking into account the important pathogenetic role of microcirculatory disorders in development of involutional processes, the observed changes in parameters of the microcirculation-tissue system may be considered an objective basis for achieving a stable therapeutic effect in management of patients with involutional skin changes associated with the metabolic syndrome.

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