Evaluation of the hypocoagulatory role of the lungs using thromboelastography in postpartum women with multiple organ failure

Abstract

Aim. To evaluate the hypocoagulatory role of the lungs in postpartum women with multiple organ failure using thromboelastography.Materials and methods. Sixty-six postpartum women aged 19 to 45 with multiple organ failure were examined. Postpartum women were divided into three groups depending on the nonrespiratory lung function impairment stage.The first group included 23 (34.8%) postpartum women with compensated nonrespiratory pulmonary function; the second group included 24 (36.4%) postpartum women with subcompensated stage of nonrespiratory pulmonary function disorder; the third group included 19 (28.8%) postpartum women with a decompensated form of nonrespiratory pulmonary function disorder.Results and discussion. When analyzing the results of studies in healthy individuals noted TEG constant R reflecting the rate of thromboplastin formation. Thrombin constant K, nonspecific coagulation constant R+K, prothrombin use constant R/K, T - total clotting, syneresis (compaction) C are prolonged in the arterial blood flowing from the lungs compared to the mixed venous blood.Conclusions. In healthy humans, the lungs act as a coagulation filter, reducing the hemostatic potential of the blood. The hypocoagulatory function of the lungs in postpartum women with multiple organ failure is impaired in stages. The thromboelastographic hemostasis study allows rapid and complete assessment of the hypocoagulatory role of the lungs in parturient women with multiple organ failure.