Abstract
The overall objective of this study was to evaluate the hemolysing action of Naja nigricollis venom on rabbit blood. To carry out this study, three batches of three rabbits were formed with two control batches and one experimental batch. Each control lot is composed of three rabbits (males or females) while the experimental lot is composed of two males and one female. Each rabbit from the control lots was separately collected in the purple tube (EDTA) and transported to the laboratory for analysis. The rabbits from the experimental batch were also collected distinctly a few minutes after the injection of the venom of Naja nigricollis for the analysis of haematological parameters. However, before the analysis of the hematological parameters of the rabbits from the control and experimental batches, an in vitro hemolysis test of Naja nigricollis venom was performed to verify its hemolysing power. The results showed that Naja nigricollis venom has a dose-dependent in vitro hemolysing power. As for the haemogram, it revealed that the venom of Naja nigricollis has a decreasing effect on blood cells (red and white blood cells), on haemoglobin and on haematocrit, and an elevation on MGVs thus promoting anaemia.
Highlights
Envenimation is the introduction into the body of a toxic substance, venom, due to the bite of a snake, the sting of a scorpion, a wasp, etc
Each control lot is composed of three rabbits while the experimental lot is composed of two males and one female
Each rabbit from the control lots was separately collected in the purple tube (EDTA) and transported to the laboratory for analysis
Summary
Envenimation is the introduction into the body of a toxic substance, venom, due to the bite of a snake, the sting of a scorpion, a wasp, etc. The most dangerous is that caused by snake bites [1], [12]. Venom contains a complex mixture of enzymes, peptides and proteins of low relative molecular weight, with specific chemical and biological activities, which can lead to death from neurological and/or hematological disorders [9], [12]. This case of envenimation is a problem affecting the five continents of the world. Africa records more than one million bites causing 600,000 cases of envenomation. In Africa, nearly 250,000 patients are treated, there are more than 20,000 deaths [4], [5]
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