Abstract
Background For centuries, medicinal plants have been extensively used in wound healing of burn injuries. The aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. Materials and Methods. This experimental study was conducted on 24 male Sprague-Dawley rats with second-degree burns. The animals were randomly divided into three groups. The burns were treated with curcumin (Group B) and Hypericum perforatum (HP) on second-degree burn wounds in rats. Results All histological parameters of the control group showed statistically significant difference than the other groups (p < 0.05). There was no statistically significant difference between Groups B and C in terms of reepithelization and inflammation (p < 0.05). There was no statistically significant difference between Groups B and C in terms of reepithelization and inflammation (p < 0.05). There was no statistically significant difference between Groups B and C in terms of reepithelization and inflammation (p < 0.05). There was no statistically significant difference between Groups B and C in terms of reepithelization and inflammation (Conclusion Both curcumin and Hypericum perforatum oil are effective in burn wound healing. Our findings showed a better quality of healing in curcumin-treated rats.Hypericum perforatum (HP) on second-degree burn wounds in rats.
Highlights
Burn injury is one of the most health-threatening problems in the world
On the 21st day, reepithelization was complete in curcumin- and Hypericum perforatum-treated groups, whereas in the control group, the epidermis layer was not formed (Figure 2). e curcumin group revealed remarkable healing with decreases in inflammatory cells with increases in fibroblast proliferation and angiogenesis
On the basis of the taken photos at the 7, 14, and 21 days of the experiment, the quality of wound healing was better in the curcumin group (Figure 4). ickness of granulation tissue was significantly different between each group (p < 0.0001). e mean values of thickness of granulation tissue in the center of the wounds for curcumin, Hypericum perforatum and control groups are shown in (Table 3)
Summary
Burn wound healing is a complex process including inflammation, granulation, and remodeling of the tissue. The natural yellow pigment in turmeric, is isolated from the plant C. longa [3]. Medicinal plants have been extensively used in wound healing of burn injuries. E aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. E burns were treated with curcumin (Group B) and Hypericum perforatum (Group C) with daily application. All histological parameters of the control group showed statistically significant difference than the other groups (p < 0.05). In the curcumin group compared with the HP group, a significant difference was observed for two parameters of fibrosis and angiogenesis (p < 0.05). Both curcumin and Hypericum perforatum oil are effective in burn wound healing. Our findings showed a better quality of healing in curcumin-treated rats
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