Evaluation of the Genoprotective and Cytoprotective Activity of Vitamin K-7 Against Doxorubicin in Bone Marrow Cells and Spleen Cells of Rats

Abstract

Doxorubicinisa chemotherapeutic drug that showed a great treatment potential, unfortunately, itis notselective to cancer cells and affects many other cells. Vitamin K-7 is available from nutritional sources anddietary supplements,it has been reported that it had many beneficial effects.Objective: Evaluate the protective effect of vitamin K-7 against cytotoxicity and genotoxicity induced bydoxorubicin.Method: Seventy-two rats divided equally into two groups, each group divided into 6 subgroups as followingGroup I: received distilled water. Group II: receiveda single dose of Doxorubicin (15mg/kg). Group III:received Vitamin K-7(16?g/kg) for 11 successive days. Group IV: received Vitamin K-7 (48?g/kg) for 11successive days.Group V: received Vitamin K-7(16?g/kg) for 11 consecutive days before a single dose ofDoxorubicin 15mg/kg on day11. Group VI: received Vitamin K-7 at a dose of 48 ?g/kg for 11 consecutivedays before a single dose of Doxorubicin 15 mg/kgat day 11.Results: Group II caused significant reduction (P<0.05) in mitotic index associated with an elevation in themicronucleus appearance and the total chromosomal aberrations compared to those of control Group I rats;meanwhile, Groups IV and V decreased chromosomal aberration, micronucleus appearance and increasemitotic index compared to Group II rats treated with doxorubicin.Conclusion: Vitamin K-7 has protective effects against genotoxicity and cytotoxicity induced by doxorubicin.