Abstract
Background: The use of chemotherapy in the peritoneum seeks to explore pharmacokinetic properties not possible with the use of systemic chemotherapy. PIPAC aims to optimize the distribution and depth of penetration of therapeutic agents into the peritoneal space. This form of application uses devices that aerosolize therapeutic substances using high injection pressure atomization. This article seeks to describe the feasibility in an animal model of a new modality of aerosolization of a therapeutic substance in the peritoneum using ultrasonic energy.
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