Abstract
Evaluation of the Effects of Fullerene C60 Nanoparticles on Oxidative Stress Parameters at Liver and Brain of Normal Rats
Highlights
An important role of reactive oxygen species (ROS) accumulation has been demonstrated in the pathogenesis of numerous chronic diseases [1,2]
Fullerene C60 significantly increased the value of Catalase activity (CAT) activity by 66% and MDA levels by 68%, while decreased Superoxide Dismutase (SOD) activity by 33% at liver of treated rats compared to untreated animals (P
Our findings indicated that oral administration of fullerene C60 nanoparticles differently changed the oxidative stress parameters in liver and brain in normal condition
Summary
An important role of reactive oxygen species (ROS) accumulation has been demonstrated in the pathogenesis of numerous chronic diseases [1,2]. In physiological situations, these free radicals are frequently produced in the tissues. These free radicals are frequently produced in the tissues They are removed by the antioxidant defense systems to keep a redox balance [3,4]. It is believed that to keep the balance between oxidation and antioxidation, the endogenous antioxidant defense system is not sufficient, and the exogenous antioxidants are continuous demand to prevent stress and ageingrelated disorders [5]. Using several antioxidants prevented progression of chronic neurodegenerative disorders for instance Parkinson’s disease (PD) or Alzheimer’s disease (AD) as well as delayed aging [5,8]
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