Abstract
The concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) increased in the brain of dogs and rats after complete hepatectomy, the increases of 5-HIAA being greater than those of 5-HT. The increase in concentration of both 5-hydroxyindoles was much smaller than that of the precursor, tryptophan (Try). The demonstration of radioactive 5-HT and 5-HIAA in the brain of normal and hepatectomized rats after the intradiencephalic injection of l-Try-3- 14C indicated that hydroxylation of Try occurred in brain in vivo. However, the intravenous injection of Try (33 mg/kg) resulted in definite increases in the concentration of 5-hydroxyindoles in the brain of normal rats and only marginal increases in the brain of hepatectomized rats. After intravenous injection of d, l-5-hydroxytryptophan, conversion to 5-HT was essentially similar in normal dogs and in dogs in coma after complete hepatectomy.
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