Abstract
The occurrence and development of breast cancer are closely related to dietary factors, especially dietary patterns. This study was to investigate the effects of dietary patterns on the process of tumor metastasis by in vivo circulating tumor cell (CTC) capture strategy and monitoring changes of CTC numbers in breast tumor mice model. Meanwhile, the effects of different dietary patterns on the development of lung metastases of breast cancer and the volume and weight of carcinoma in situ were investigated. In this study, the increase in the number of CTCs was significantly promoted by dietary patterns such as high-salt diet, high-sugar diet, and high-fat diet, while it was delayed by ketogenic diet, low-fat diet, low-protein diet, diet restriction, and Mediterranean diet. These results indicated that the in vivo capture and detection of CTCs provides a convenient method for real-time cancer metastasis monitoring, and through in-depth study of the effects of different dietary patterns on tumor growth and metastasis, it can expand a new horizon in future cancer treatments.
Highlights
MethodsEpCAM rabbit polyclonal antibody was obtained from Bioss Biological Technology
This study provided valuable suggestions for people to eat properly to achieve the purpose of study provided valuable suggestions for people to eat properly to achieve the purpose of cancer prevention or treatment, and this is an important report evaluating the effects of cancer prevention or treatment, and this is an important report evaluating the effects of multiple dietary patterns on breast cancer metastasis simultaneously
This study is based on in vivo capture of circulating tumor cell (CTC) to evaluate the effects of multiple dietary patterns on the process of breast cancer through monitoring the number of
Summary
EpCAM rabbit polyclonal antibody was obtained from Bioss Biological Technology. EpCAM rabbit polyclonal antibody was obtained Bioss Biological Technology Co., Ltd. Anti-CD45-FITC specific for from leukocytes and 40 ,6-diamidino-2Co., Ltd. 4′,6-diamidino-2phenylindole (DAPI) were purchased from Invitrogen (Carlsbad, CA, USA). Were purchased from Invitrogen (Carlsbad, CA, USA).
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