Evaluation of the effects garlic extract with low level laser on healing cutaneous wounds in rabbits model

Abstract

This study was intended to assess the healing activity of effect of garlic extract 15% combined with the 8j /cm2 diode lasers by topical application on the skin experimentally in full - thickness cutaneous wounds in a rabbit's model. For this reason, this investigation was conducted on sixteen adult and clinically healthy males' rabbits, full-thickness circular skin wounds (1 cm in diameter) were made on the back of each animal. The animals were arbitrarily divided into two equal groups of eight rabbit's for each. In control group, the injuries were left without treatment. While in treatment group, were treated by a topical application of the garlic extract 0.15% using garlic extract, for two times /day for 7 successive days, involving the wound with combination irradiated by diode laser at a wave length of (820 nm), frequency of (10 KHz), power output (50mW), spot size (1 cm), energy density (8 J/cm2) and exposure time (5 second) for seven consecutive days. The clinical assessment of treated wounds demonstrated that the injury healing process contraction%, Re-epithilization % and total wound healing % were signifecantly P<0.05 than that of control wounds at 14 days of the investigation.