Evaluation of the effectiveness of the main systemic antibiotics at the first stage of treatment of generalized aggressive periodontitis

Abstract

Relevance: the aims of the study was to compare the effectiveness of the use of various systemic antibiotics in patients with aggressive generalized periodontitis. A comparative study of systemic antibiotic therapy using modern molecular biological methods is important in modern periodontology.Materials and methods: a prospective, randomized, controlled study of 112 patients with generalized aggressive periodontitis before and after using systemic antibiotics with real-time PCR (GE/ml) of major periodontal pathogens. The median was chosen as a quantitative measure of central tendency. Upper and lower quartiles were used for interval estimation.Results: moxifloxacin is most effective against Porphyromonas gingivalis (median 102,1 GE/ml) and Tannerella forsythensis (median 103,7 GE/ml). Also effective and reliably suppressed Porphyromonas gingivalis and Treponema denticola when lincomycin was used (medians 103,2, 102,7 GE/ml).Conclusion: the most effective systemic antibiotics are moxifloxacin and lincomycin, which significantly reduced the number of Porphyromonas gingivalis, Tannerella forsythensis, and Treponema denticola in periodontal pockets.