Abstract
Objectives: The aim of the study was to assess the efficacy of 5% hyaluronic acid crem for the treatment of seborrheic dermatitis of the face. Materials and methods: A total of 49 patients (28 men and 21 women, age from 31 to 64 years) with seborrheic dermatitis of the face were selected for the study. A single-site, prospective observational study of 5% hyaluronic acid cream for the treatment of facial seborrheic dermatitis was conducted from 2016 to 2020. All patients underwent a thorough clinical examination according to the generally accepted scheme. Treatment planning includes a thorough history and physical examination, preoperative laboratory examination. At each visit, degrees of scale, erythema, and pruritus were evaluated. To assess the effectiveness of patients were given a questionnaire to fill out the questions. The questionnaire evaluated the 5% hyaluronic acid crem effectiveness of the treatment. Outcome was the evolution of the Investigator Global Assessment (IGA) scale, assessing erythema, scale / scaling, seborrhea and pruritus, all measured on a five-point scale, from 0: no signs / symptoms to 4: very severe sign / symptom. Subjects were assessed at baseline after 4 and 8 weeks. Results: Baseline IGA scores (mean ± SD) were 9 ± 3 (range: 5-13). The use of the EDS significantly reduced the IGA score by 67% at 4 week and by 83% at 8 week. The condition improved from baseline in 92.3% of subjects. Conclusion: 5% hyaluronic acid crem has been effective in reducing erythema, scales, seborrhea, and itching. No local side effects were reported.
Highlights
Seborrheic dermatitis of the face is a chronic and recurrent inflammatory skin disease that occurs in areas of the face that are rich in sebaceous gland and is a common dermatological disease worldwide, with a high frequency during puberty and a peak in the third and fourth decades of life [1, 2]
The use of the 5% hyaluronic acid significantly reduced the Investigator Global Assessment (IGA) score by 67% at week 4 and by 83% at week 8. 5% hyaluronic acid has been effective in reducing erythema, scales, seborrhea, and itching
Multiple factors have been identified as predisposing to facial seborrheic dermatitis, and understanding of the causes and pathogenesis of facial seborrheic dermatitis has improved thanks to advances in microbiological and analytical techniques
Summary
Seborrheic dermatitis of the face is a chronic and recurrent inflammatory skin disease that occurs in areas of the face that are rich in sebaceous gland and is a common dermatological disease worldwide, with a high frequency during puberty and a peak in the third and fourth decades of life [1, 2]. Many factors have been identified as predisposing, and understanding of the causes and pathogenesis has improved due to advances in microbiological and analytical methods [3,4]. Anywhere we have a proliferation of sebaceous (oil) glands.This inflammatory response disrupts the differentiation of the epidermis and barrier function, and itching and combing can cause further disturbance: as a result, a cycle of immunostimulation, abnormal differentiation of the epidermis and violation of the barrier occur
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