Abstract
ABSTRACT The objective of this study was to evaluate the effect of ozonized olive oil with or without laser photobiomodulation (LPBM) on the healing process of traumatic ulcers in rat tongues. Sixty male Wistar rats underwent tongue ulceration using a six-mm diameter punch. Animals were divided into four experimental groups: control-G1, LPBM-G2, Ozonized olive oil-G3, and LPBM + Ozonized olive oil-G4. Euthanasia was performed on days three, seven, and 14. Clinical analysis of the wound size and histomorphological evaluation using hematoxylin and eosin and Sirius red staining were conducted to identify edema, inflammatory infiltrates, fibroblastic cellularity, reepithelialization, and collagen characterization. Descriptive and exploratory analyses were performed using R and inferential statistics were calculated using Fisher’s exact tests, with a significance level of 5%. G2 and G3 positively modulated the repair phases clinically (p < 0.05) and histologically, showing reepithelialization, fibroblastic population, and thick collagen fiber deposition from the 3rd day of the experiment. G4 exhibited a significant difference from G1 in the clinical parameters (p < 0.05), but did not demonstrate superiority in histomorphological terms of tissue repair. Isolated use of LPBM and ozonized olive oil improved tissue repair in rat tongues.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
