Abstract
Expression of glutamine synthetase (GS) in normal liver is restricted to pericentrivenular hepatocytes. Immunohistochemistry (IHC) for GS has emerged as a key marker of beta-catenin-activated hepatocellular adenoma, focal nodular hyperplasia, and hepatocellular carcinoma (HCC). Upon staining several HCCs with GS, we observed novel staining patterns in the regenerative nodules of background cirrhosis. We hypothesized that these patterns might correlate …
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