Abstract
1. 1. In the light of the relationship between administration schedule and compliance, comparison data between divided dose regimen and one-time daily dosage of antidepressant drugs are reviewed in terms of therapeutic and pharmacokinetic equivalence. 2. 2. Divided (b.i.d.) and single (morning) doses of nomifensine (100–200 mg/die) were studied in patients affected with neurotic depression. Clinical results show that the two regimens do not differentiate as for antidepressant eff i cacy and safety. 3. 3. Nomifensine findings are compared to those obtained with amitriptyline (50–150 mg) given in three different schedules (three daily doses, single dose at morning, single dose at night).
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