Evaluation of the Biological Efficacy and Physicochemical Evaluation of Toothpaste Prepared from Few Types of Plant Extracts against Some Pathogenic Bacteria Isolated from the Mouth

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The demand for a herbal-based products such as toothpaste is high these days. Consumers believed that herbal-based toothpaste are safe, effective and less toxic because few and safe chemicals is used as compared to synthetically produced toothpaste. Therefore, this study was amied to formulate and evaluate new polyherbal toothpaste containing herbal extracts available to treat periodontal problems. The polyherbal toothpaste was formulated using three herbal extracts namely lemongrass (Cymbopogon citratus L.) marjoram (Qriganum majorana L.) and salivia (Salvia officinalis L.) and tested against Streptococcus mitis-orul Streptococcus pyogen, Streptococcus mutans, Enterococcus faecalis Enterococcus faecium, Gemella morbilloe, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Escherichia coli, Klebsiella pneumonia ssp, Acinetobacter baumannii complex, Pseudomonas aeruginosa, with different concentrations varying from 100, 50, 25, 12.5, and 6.25 mg/mL. The significant inhibition has seen against Streptococcus mutans (27 mm) and there is no inhibition for both Acinetobacter baumannii complex and P. aeruginosa. The formulated toothpaste was also evaluated with the standard physiochemical parameters along with the antimicrobial activity. it opens a window for future study to enhance the ability of the toothpaste and to prove the efficacy and safety of the formulated toothpaste. Then a comparison was made with commercial toothpastes for three selected types