Abstract
Praziquantel liposomes were prepared from different mole fractions of l-α-dipalmitoylphosphatidylcholine and cholesterol according to the thin film method. The liposomes having optimum loading capacity for the drug were evaluated regarding their targeting properties towards the liver in mice. The results revealed pronounced targeting to the liver as well as sustained release properties which reflect its prophylactic action of the encapsulated drug towards Schistosomiasis. This was clearly demonstrated by an increase in the survival rate of mice as well as a statistically significant decrease in the hepatic worm count.
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