Evaluation of the antimicrobial activity of iron oxide nanocatalyst doped with nanoparticles

Pâmela Cristine Ladwig Muraro,Gabriela Pereira Chuy,Bruno Stefanello Vizzotto,William Leonardo Da Silva,Sérgio Roberto Mortari

doi:10.37779/nt.v21i3.3558

Pâmela Cristine Ladwig Muraro, Gabriela Pereira Chuy + Show 3 more

Open Access

https://doi.org/10.37779/nt.v21i3.3558

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Abstract

The synthesis of metallic nanocatalysts has been a new technological alternative found by researchers to corroborate in the Treatment of Water and Sewer because they have physical and chemical properties for the disinfection of water, analyzed through antimicrobial activity. Thus, this study aims to evaluate the antimicrobial activity of iron oxide nanocatalysts (undoped and dioped with metallic nanoparticles). The synthesis of the iron oxide nanocatalysts was by the sodium borohydride oxy-reduction method and doping by impregnation method. Two methodologies were used to assess antimicrobial activity, the method by Disc-diffusion and Minimum Inhibitory Concentration (MIC) using the strains of Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922) The results showed that the majority of the nanocatalysts did not show antimicrobial activity, whereas the pure nanocatalyst in the proportion of 2:1 (w/w) showed biological activity up to the concentration of 1.25 mg L -1 .

Highlights

The growing trend of microbial infections, the rapid spread of the resistance of microorganisms to antimicrobials and the development of multidrug-resistant strains through mutations represent a major risk to public health on a global scale; will be used in biomedicine and health (AKBAR et al, 2020).Nanocatalysts (NCs) have become a relevant topic for research in recent years due to their extensive applications in various fields, such as diagnosis, biomarkers, cell labeling, antimicrobial agents, drug delivery and cancer therapy (MOUSAVI et al, 2018)
For the synthesis of the iron oxide nanocatalyst (FeNPs), chemical precipitation methodology was used with sodium borohydride like reducing agent, according to the literature (SUN et al, 2006)
It was observed that there was no inhibition of the growth of microorganisms in the plates, there was no homogeneous distribution of the compounds on the disk, probably not allowing sufficient contact of these with the seeded plate, which prevented the use of the disc-diffusion assay in a satisfactory way to determine the antimicrobial activity

Summary

Introduction

The growing trend of microbial infections, the rapid spread of the resistance of microorganisms to antimicrobials and the development of multidrug-resistant strains through mutations represent a major risk to public health on a global scale; will be used in biomedicine and health (AKBAR et al, 2020).Nanocatalysts (NCs) have become a relevant topic for research in recent years due to their extensive applications in various fields, such as diagnosis, biomarkers, cell labeling, antimicrobial agents, drug delivery and cancer therapy (MOUSAVI et al, 2018). NCs with metallic oxide have been explored due to their antimicrobial activity against a variety of microorganisms that are known to cause common hospital-acquired infections (ABO-ZEID; WILLIAMS, 2019). They can be a very promising path for the development of new antimicrobial therapeutic alternatives, such as topical use for bacterial infections (RIOS et al, 2016). Microorganisms are not able to develop resistance to the production of ROS, since they attack the different sites and different biomolecules of the organism, resulting in their oxidation and cell death T (ABO-ZEID; WILLIAMS, 2019)

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