Evaluation of the antiischemic effect of a prolonged form of trimetazidine in patients with stable angina pectoris using speckle-tracking technique

Abstract

Studies of global and segmental myocardial contractility using the speckle-tracking technique in patients suffering from stable angina pectoris compared to healthy individuals are presented. It was revealed that, in patients suffering from stable angina pectoris, the values of longitudinal deformation in the anterolateral and apical segments of the left ventricle, as well as global longitudinal deformation, decrease. Differences in longitudinal myocardial deformation in other segments were not observed in the subjects. Possible causes of a decrease in the longitudinal deformation of the myocardium, both in general and in individual segments of the left ventricle, are examined. The data on longitudinal segmental deformity of the left ventricle on the background of anti-ischemic therapy are presented. A direct correlation between the values of the global longitudinal deformation and the distance traveled by patients before the development of an angina attack was revealed.In addition, a direct correlation was found between the longitudinal deformation of the myocardium in the anterior septal region of the left ventricle and exercise tolerance. Adding a prolonged form of trimetazidine to complex anti-ischemic therapy leads to a significant increase in segmental and global deformity of the left ventricle, which is accompanied by a decrease in the daily need for nitroglycerin and an increase in exercise tolerance. The lack of dynamics of the longitudinal strain in the basal parts of the left ventricle during treatment may be due to the development of cardiosclerosis.