Abstract
BackgroundThe search for novel pharmacotherapy from medicinal plants for central nervous system (CNS) disorders has become of importance since new agents with improved efficacy for more effective therapy are required. Sesamum indicum has been extensively used in Bangladesh and other Indian Subcontinent as medication for various diseases including CNS disorders. It was found to have antioxidant, antitumor, antihypertensive, neuroprotective, hypoglycemic, antimicrobial, anticonvulsant and wound healing activity.ResultsThe result showed robust and dose-dependent antidepressant-like activity. There are statistically significant (p* < 0.05) reductions in the duration of immobility time both in forced swimming and tail suspension test. In open field test, measurement of locomotion, defecation and rearing are evaluated. There is statistically significant (p* < 0.05) increase in locomotion, rearing and defecation of mice compared to control group.ConclusionsThese results clearly demonstrates that methanolic extract of the seeds of Sesamum indicum has potential antidepressant activity and further studies should be conducted to identify, isolate and evaluate its potential active compound responsible for such effect.
Highlights
The search for novel pharmacotherapy from medicinal plants for central nervous system (CNS) disorders has become of importance since new agents with improved efficacy for more effective therapy are required
Depression is becoming a rising concern in the current world as almost 450 million people around the world suffer from it according to WHO
Tail suspension test (TST) This method was developed by Steru (1985) and is used with slight modifications [18]. This method was employed on the observation that a mouse suspended by the tail shows alternate agitation and immobility which indicates a state of depression
Summary
The search for novel pharmacotherapy from medicinal plants for central nervous system (CNS) disorders has become of importance since new agents with improved efficacy for more effective therapy are required. Depression is becoming a rising concern in the current world as almost 450 million people around the world suffer from it according to WHO. One in four women and one in six men experience depression in their life [3], and up to 65% of individuals have recurrent episodes of the disorder [4,5,6]. Depression has been found to be the fourth leading cause of overall disease burden and the leading cause of nonfatal disease burden worldwide [7]. Drugs such as Tricyclic antidepressants, Monoamine Oxidase Inhibitors, Selective Serotonin
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