Abstract
Background - Genetic factors likely play some role in causing a high blood pressure. About 40% of patients with primary hypertension have genetic predisposition. It is a well documented fact that sympathetic dominance increases heart rate and blood pressure and the same has been observed in young normotensive off springs of hypertensive parents. Aim - Our present study was focused to evaluate blood pressure responses to isometric hand grip exercise test in children of hypertensive and non- hypertensive parents. Methods - The present study was conducted in 50 healthy subjects doing MBBS, 25 of whom had a positive family history and 25 had no family history of hypertension. Isometric hand grip test for sympathetic evaluation was carried out in both the groups following measurement of resting blood pressure. Rise in diastolic blood pressure measured during isometric hand grip taken as a test response. Results - Results were tabulated and analysed using paired t test, p value <0.001 was considered as significant. Higher values were obtained in diastolic and systolic blood pressure in children of hypertensive parents at rest when compared to age matched controls while during isometric hand grip increase in diastolic blood pressure in offspring of hypertensives was statistically significant. Findings are suggestive of an increased sympathetic dominance in children of hypertensive. Conclusion - The present study suggests that healthy children of hypertensive parents have a higher sympathetic dominance when compared to healthy children of non hypertensive parents. DOI: 10.21276/AABS.2017.1351
Highlights
Hypertension is one of the most important causes of premature deaths occurring worldwide and is claimed to be a silent killer by the World Health Organization
The present study suggests that healthy children of hypertensive parents have a higher sympathetic dominance when compared to healthy children of non hypertensive parents
Out of them 25(males & females) subjects had a positive family history of hypertension (FH+) and other 25(males & females) subjects belong to non-hypertensive parents (FH-)
Summary
In India, hypertension is the third most important risk factor burdening both cardiovascular health and health care systems in the country. It is one of the major risk factor for cardiovascular mortality which accounts 20-50% of all deaths. Early diagnosis can prevent about 3 lakh deaths in India.[2] increasing prevalence of the condition is blamed on life style factors, such as stress, physical inactivity, a salt rich diet created by processed , fatty food and alcohol and tobacco use.[3] Genetic factors play important role in causing a high blood pressure. It is a well documented fact that sympathetic dominance increases heart rate and blood pressure and the same has been observed in young normotensive off springs of hypertensive parents
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