Abstract
Heamolytic disease of the newborn is a neonatal disease associated with red cells heamolysis resulting from red cell antigens of the foetus and mother red cells antibodies. This study involved a cross sectional laboratory based analytical survey, eighty neonates with pyrexia of unknown origin and twenty neonates apparently healthy were selectected for this study. ABO and Rh blood group, Direct Coombs’ test, Glucose-6-phosphate dehydrogenase estimation and blood culture were performed on blood samples collected from each neonate. Blood group O had the highest number of neonates (60% control; 61% test); 80% and 81.3% of the control and test neonates are Rh positive respectively. None of the control subjects are positive to DCT while 5% of test subjects positive to DCT; 4% and 8.7% of the control and test respectively are positive to G6-PD deficiency. The study recorded 0% growth in blood culture of control subjects while 2.5% of the neonates blood samples yielded when cultured. Though prevalence rate of HDN in our society is diminishing gradually based on this study, there is need to look inwardly to other aetiological factors that can cause HDN apart from blood group incompatibility, since sudden infant death is on increase now.
Highlights
Haemolytic disease of the newborn (HDN), erythroblastosis fetalis, is associated with foetal red cell destructionHow to cite this paper: Fadairo, J.K., Aladenika, S.T., Osaiyuwu, C., Olaniyan, M.F. and Aghatise, K. (2014) Evaluation of Some Etiological Factors of Haemolytic Disease of the New Born in Ile-Ife
This study examined pattern and prevalence of ABO Blood Group and Rhesus Incompatibility among Neonates in, the distribution of G6PD deficiency among neonates sub infected of HDN in Ile-Ife and and bacteraemia in HDN
Haemolytic Disease of the New born, known as erythroblastosis fetalis, is a neonatal disease characterized by the destruction of the red blood cells of the affected neonates [5]
Summary
Haemolytic disease of the newborn (HDN), erythroblastosis fetalis, is associated with foetal red cell destructionHow to cite this paper: Fadairo, J.K., Aladenika, S.T., Osaiyuwu, C., Olaniyan, M.F. and Aghatise, K. (2014) Evaluation of Some Etiological Factors of Haemolytic Disease of the New Born in Ile-Ife. Haemolytic disease of the newborn (HDN), erythroblastosis fetalis, is associated with foetal red cell destruction. The IgG antibodies bind to foetal red cells, and in turn, these are destroyed following adherence to Fc receptors on macrophages in the spleen, by phagocytosis and extra cellular lysis. Haemolytic disease of the newborn can result from incompatibilities caused by many other red cell antibodies, this occurrence is much less frequent [1]. The Rh blood group antigen D is the most important cause of a family of inherited antigens. The theory of inheritance put forward by Fisher and Race states that there are three pairs of antigen, Dd, Cc and Ee. The presence of Rh (D) indicates Rh positivity while the absence of Rh (D) indicates Rh negativity
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
