Abstract
The effect has been investigated of data smoothing on the precision and accuracy of peak height ratio (analyte/isotopically-labelled internal standard) determination by gas chromatography/mass spectrometry with dual ion monitoring. The smoothing routines evaluated were all based on the moving average principle but differed with respect to weighting factors and filter width. Smoothing was shown to achieve only a minor improvement in precision and introduced significant bias in the peak height ratio calculation. In contrast, determination of response ratios by linear regression of analyte and internal standard signals achieved superior precision without the introduction of significant bias.
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