Abstract
BackgroundSerum14-3-3η protein plays an important role in the pathogenesis of rheumatoid arthritis (RA) as it is a joint-derived proinflammatory mediator. Semaphorin3A (Sema3A) plays an immune regulatory and bone remodeling role in many autoimmune diseases. Their role in rheumatoid arthritis needs to be evaluated for diagnostic and prognostic prospective values.ResultsThe serum level of protein 14-3-3n was significantly higher in patients with RA than those in healthy controls. Serum 14-3-3η has a significant positive correlation with RF and ACPA, but not with either DAS28, ESR, or CRP. Serum 14-3-3η levels were significantly correlated with radiographically assessed joint damage. Serum Sema3A levels were decreased in rheumatoid arthritis patients compared to controls. There were also negative correlations with disease duration and activity score (DAS28), ESR, CRP, and RF.ConclusionThe discriminative ability of 14-3-3η was comparable to RF and ACPA enhancing its diagnostic capacity. Sema 3A might serve as a predictive marker for radiographic severity and could have a potential therapeutic role in RA.
Highlights
Serum14-3-3η protein plays an important role in the pathogenesis of rheumatoid arthritis (RA) as it is a joint-derived proinflammatory mediator
Our objective is to study the role of these two new markers in rheumatoid arthritis
All patients were subjected to full medical history taking, complete clinical examination, evaluation of disease activity using Disease Activity Score 28 (DAS28), Erythrocyte sedimentation rate (ESR), visual analog scale, and simplified disease activity index (SDAI) [16, 17]
Summary
Serum14-3-3η protein plays an important role in the pathogenesis of rheumatoid arthritis (RA) as it is a joint-derived proinflammatory mediator. Semaphorin3A (Sema3A) plays an immune regulatory and bone remodeling role in many autoimmune diseases. Their role in rheumatoid arthritis needs to be evaluated for diagnostic and prognostic prospective values. The presence of autoantibodies to immunoglobulin G (rheumatoid factor—RF) and citrullinated proteins (anticitrullinated protein antibodies—ACPAs) are characteristic to RA They are absent in the sera of some patients [3]. The 14-3-3 family of intracellular chaperone proteins consists of seven isoforms: alpha/beta (α/β), epsilon (ε), gamma (γ), eta (η), tau (τ), zeta (ζ), and sigma (σ) [7] These proteins interact with more than 200 intracellular proteins to play a role in protein synthesis, cell cycle regulation, control of metabolism, protein trafficking, apoptosis, control of gene transcription, and cytoskeletal transport [8]. Serum 14-3-3η level increases in patients with arthritis as it can induce proinflammatory cytokines, like interleukin 1β (IL-1β), tumor necrosis factorα (TNF-α), and IL-6, and other factors leading to a joint
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
