Evaluation of serum uric acid in type two diabetic nephropathy patients

Abstract

Introduction: Diabetic nephropathy is one of the leading complications of longstanding diabetes mellitus. With the background of inflammation, there is need for laboratory tests for early diagnosis and prevention of diabetic nephropathy. Materials and Methods: A cross sectional study done after screening, patients satisfying the inclusion and exclusion criteria 50 patients of type II diabetic patients with nephropathy (Group I) and 50 type II diabetic patients without nephropathy(Group II) were included in the study. Serum uric acid was estimated by standard enzymatic uricase method on autoanalyser ADVIA 1800. Serum urea was estimated by urease method and serum creatinine was estimated by Jaffe’s method and Sr.Uric Acid by uricase method using fully autoanalyzer ADVIA 1800. Results: The mean age in group I was 59 + 9.28 years and group II was 56.2 + 11.47 years. The serum Uric Acid was 9.51 +2.46 (mg/dl) in group I and statistically significant (p+ 1.68 mg/dl. The Serum creatinine in group I (6.68 + 2.94 mg/dl) and statistically significant p+ 0.77 mg/dl). There was positive correlation between Sr.Uric Acid and Sr. Creatinine (r=0.625, p Conclusion: Regular detection can help the clinician to take appropriate action to delay complications which in turn may help preserve renal function in DN patients. Keywords: Creatinine, Urea, Fasting blood glucose, Urine albumin.