Ratio of Urinary Uric Acid Levels and Serum Uric Acid in Type 2 Diabetes Mellitus

Abstract

Diabetes Mellitus (DM) belongs to the group of metabolic diseases. The long-term complications of diabetes such as: diabetic retinopathy, neuropathy, and nephropathy, can be prevented or reduced by controlling the blood glucose levels. Impaired glucose tolerance, hypertension and dyslipidemia can decrease the disappearance from proximal tubules resulting in an increase in serum uric acid. The aim of the study to know the ratio of uric acid urine/serum in DMT2 with controls. This research study used a cross sectional study was and conducted on 35 samples of type 2 diabetes mellitus and 35 control samples of In- and Out-patient Clinics at the Dr. Wahidin Sudirohusodo Hospital, Makassar. The blood glucose, uric acid levels and urine uric acid were examined by ABX Pentra 400 (colorimetric method). The number of DMT2 male patients was higher than females. Most of their age were between 50−54 years. The ratio of the urinary levels of urine/serum UA was positively correlated to: age, sex, urine UA in DMT2 and control. Their data were analyzed with unpaired t test (p = 0.00). This research showed that the ratio of urine/serum UA in DMT2 was 1.5 times than the controls. The results of this study showed an increase in the ratio of urinary levels of serum uric acid as 1.5 times higher than the controls.