Evaluation of serum soluble ST2 and brain natriuretic peptide in patients with acute heart failure and prognosis

Abstract

Objective To study Evaluation of serum soluble ST2 protein and brain natriuretic peptide(NT-proBNP) in patients with acute heart failure and prognosis of patients with acute heart failure. Methods Fifty cases patients with acute heart failure from April 2014 to April 2015 in the First Hospital of Traditional Chinese and Western Medicine of Beijing were researched.Detection of all patients with serum ST2, NT-proBNP, 50 patients with acute heart failure were divided into heart failure group, 50 healthy persons were selected as the control group.The control group and the observation group general heart failure data, the observation group and the control group of cardiac biomarker blood level, cardiac function level NT-proBNP blood concentration level, classification of cardiac function between ST2 blood concentration level were compared. Results Cr, BUN of heart failure group were higher than the control group, there was no significant difference between other indicators(P>0.05). ST2((0.46±0.07) ng/L) in heart failure group was lower than the control group((0.66±0.20) ng/L), NT-proBNP((4160.20±57.49) ng/L )was higher than the control group((58.97±4.39) ng/L), heart function IV NT-proBNP blood concentration of the highest (9 428.29±75.93) ng/L, followed by grade III (1 921.01±30.27) ng/L, the second lowest (321.02±16.80) ng/L, (P<0.01). Heart function IV level ST2 blood concentration was the highest(1.95±0.69) ng/L, followed by grade III(1.27±0.61) ng/L, class II minimum(0.78±0.24) ng/L(P<0.01). Conclusion The serum ST2 and NT-proBNP are used to detect the patients with acute heart failure, can provide accurate diagnosis basis, has a very important value judgment on the classification and prognosis. Key words: Serum ST2; Brain natriuretic peptide; Acute heart failure