Evaluation of Serum Homocysteine and Nitric Oxide Levels in Women with Polycystic Ovarian Syndrome and Periodontal Diseases

Abstract

Polycystic ovary syndrome (PCOS) and periodontal diseases are common chronic inflammatory disorders. PCOS is a complicated condition affects overall health and causes broad spectrum changes that affect periodontal health status. Available evidence suggests that oxidative stress might comprise a link for the association between periodontal diseases and components of the metabolic syndrome. Both homocysteine (Hcy) and nitric oxide (NO) are considered to reflect the strength of oxidative stress. The aims of the study were to compare the periodontal health condition among the study groups (gingivitis, gingivitis +PCOS, chronic periodontitis (CP) and CP + PCOS group) by measuring the clinical periodontal parameters (Plaque Index (PLI), Gingival Index (GI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL), and measure serum (Hcy) and (NO) and compare their levels between study groups , then correlate between these parameters with each other and with clinical periodontal parameters in order to determine the effect of PCOS on periodontal health status and levels of serum Hcy and NO.