Evaluation of serum high-sensitivity c-reactive protein, ferritin level in type 2 diabetic patients and its correlation with glycated hemoglobin in a tertiary care teaching hospital

Abstract

Background: Diabetes mellitus (DM) is a significant public health problem all over the world because of the comorbidities it causes. Serum ferritin, an acute phase reactant, is a measure of the body's iron reserves. Increased body iron reserves and subclinical hemochromatosis have been linked to the development of glucose intolerance, type 2 diabetes, metabolic syndrome, and possibly diabetic retinopathy, nephropathy, and vascular dysfunction, according to recent research. Materials and Methods: A total of 64 subjects out of which 32 type 2 diabetic patients as cases enrolled in the study and 32 healthy subjects as controls from the Medicine outpatient department. Fasting blood glucose, glycated hemoglobin (HbA1C), high-sensitivity C-reactive protein (hs-CRP), and serum ferritin were estimated in both cases and the control group. Results: In type 2 diabetics, FBG, HbA1c, and hsCRP levels are higher than in healthy people. With an increase in HbA1C, there was a significant increase in serum ferritin in type 2 diabetes individuals. In poorly controlled diabetes, HbA1c >7%, HbA1c has a positive correlation with FBG, serum ferritin, and hs CRP. Conclusion: In our study, the mean concentrations of fasting blood glucose, high-sensitivity C-reactive protein, ferritin, and HbA1C were significantly higher in type 2 diabetes patients than in controls. The hbA1c level >7 (poor control group) had higher fasting blood glucose, hs-CRP, and ferritin levels than the hbA1c level <7 groups (good control group). Fasting blood glucose, hs-CRP, and HbA1C were found to have a strong relationship in type 2 diabetes patients with poor control. Serum ferritin and hs CRP levels increased in diabetics as long as glycemic control was not achieved.